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KMID : 1123920050190010254
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 1 p.254 ~ p.261
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Effect of Xingyo-tang on Learning and Memory Performances in Mice
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Kim Ki-Bong
Chang Gyu-Tae
Kim Jang-Hyun
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Abstract
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The effects on memory and learning ability of the Korean herbal medicine, Xingyo-tang(XGT, ãêÎß÷·), which consists of Ginseng Radix(ìÑ߸) 4 g, Liriopis Tuber(ØêÚ¦ÔÏ) 40 g, Morindae Officinalis Radix(÷éнô¸) 40 g, Biotae Semen(ÛÚíìÒ) 20 g, Dioscoreae Rhizoma(ߣå·) 40 g, Euryales Semen(?ãù) 20 g, Scrophulariae Radix(úÜ߸) 40 g, Salviae Miltiorrhizae Radix(ӡ߸) 12 g, Poria(ÜÚãê) 12 g, Cuscutae Semen(ØóÞêí) 40 g, was investigated. The effects of XGT on learning and memory performance were examined in normal or memory impaired mice by using avoidance tests, Pentobarbital -induced sleep test, fear conditioning task, novel object recognition task, and water maze task. Hot water extract from XGT was used for the studies. Learning ability and memory are based on modifications of synaptic strength among neurons that are simultaneously active. Enhanced synaptic coincidence detection leads to better learning and memory. The XGT-treated (30 mg/100 g and 60 mg/100 g, p.o.) mice exhibit superior ability in learning and memorizing when performing various behavioral tasks. XGT did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests, and the ambulatory activity of normal mice in normal condition. In contrast, XGT produced ameliorating effects on the memory retrieval impairment induced by ethanol. XGT also improved the memory consolidation disability induced by electric convulsive shock (ECS). XGT extended the sleeping time induced by pentobarbital dose-dependently, suggesting its transquilizing or antianxiety action. These results suggest that XGT has an improving effect on the impaired learning through the effects on memory registration and retrieval.
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KEYWORD
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Xingyo-tang, Learning and Memory Ability
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